Endocrine Abstracts

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT (SPECT-CT 99mTc-MIBI parathyroid) is commonly used to investigate primary hyperparathyroidism (PHPT). We previously reported the sensitivity and positive predictive value of 4D CT parathyroid as the second line investigation in patients with non-diagnostic SPECT-CT 99mTc-MIBI parathyroid (https://www.endocrine-abstrac...

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT is commonly used to investigate PHPT. Our centre previously published sensitivity and specificity of 92 and 86% respectively for Tc99m-Sestamibi+I-123 subtraction. Five false-negative studies required neck exploratory surgery. One false-positive study incorrectly localised a PA which was not found in surgery (n=67). In recent years 4D-CT parathyroid has emerged as a useful technique to detect an...